For the dedicated old school gamers out there--that somehow may not already know--there appears to be a winning (albeit expensive) all-in-one updated hardware combo for gaming on Sega Genesis/Mega Drive/CD consoles:

1) Analogue Mega Sg - https://www.analogue.co/mega-sg

2) Terraonion MegaSD - https://terraonion.com/en/producto/megasd/

So, no CD support required, get the old school console look and feel, and better graphics.